Pudhom Khanitha, Teerawatananond Thapong, Chookpaiboon Supichar
Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Program in Biotechnology, Faculty of Science, Chulalongkorn Universtiy, Bangkok 10330, Thailand.
Mar Drugs. 2014 Mar 6;12(3):1271-80. doi: 10.3390/md12031271.
Three new spirobisnaphthalenes (1-3) were isolated from the mangrove-derived fungus Rhytidhysteron sp., together with five known derivatives (4-8). The structures of the compounds were established on the basis of extensive spectroscopic data, and the relative configurations of their stereogenic carbons were determined by a single-crystal X-ray crystallographic analysis. Compounds 3-5 displayed cytotoxicity against both cancer cell lines, MCF-7 and CaSki, while 2 was active only on CaSKi cells.
从源自红树林的真菌Rhytidhysteron sp.中分离出三种新的螺双萘（1-3），以及五种已知衍生物（4-8）。基于广泛的光谱数据确定了化合物的结构，并通过单晶X射线晶体学分析确定了其手性碳的相对构型。化合物3-5对MCF-7和CaSki这两种癌细胞系均显示出细胞毒性，而化合物2仅对CaSki细胞有活性。
