Kranvogl Roman, Knez Jure, Miuc Alen, Vončina Ernest, Vončina Darinka Brodnjak, Vlaisavljević Veljko
Acta Chim Slov. 2014;61(1):110-20.
A GC-MS method was successfully applied to measure simultaneously the concentrations of endocrine disrupting compounds (5 dialkyl phthalates, 9 phthalate monoesters, 3 alkylphenols and bisphenol A) in 136 male urine samples. In the present study the method was validated and concentrations of EDCs were determined. The results were compared with results from other studies. Correlations between endocrine disrupting compounds and also correlations of endocrine disrupting compounds with two semen quality parameters are presented and evaluated. Significant positive correlations were found between almost all the endocrine disrupting compounds. The parameter sum of DEHP (SUM DEHP) was positively correlated to all the endocrine disrupting compounds but negatively to two semen quality parameters. Negative correlations between the endocrine disrupting compounds and the semen quality parameters could indicate that endocrine disrupting compounds could cause reproductive problems by decreasing the semen count and quality. This research will have helped to evaluate human exposure to endocrine disrupting compounds.
一种气相色谱 - 质谱联用（GC-MS）方法成功应用于同时测定136份男性尿液样本中内分泌干扰化合物（5种邻苯二甲酸二烷基酯、9种邻苯二甲酸单酯、3种烷基酚和双酚A）的浓度。在本研究中，该方法得到验证并测定了内分泌干扰化合物的浓度。将结果与其他研究结果进行了比较。给出并评估了内分泌干扰化合物之间的相关性以及内分泌干扰化合物与两个精液质量参数的相关性。几乎所有内分泌干扰化合物之间均发现显著正相关。邻苯二甲酸二（2-乙基己基）酯总和（SUM DEHP）参数与所有内分泌干扰化合物呈正相关，但与两个精液质量参数呈负相关。内分泌干扰化合物与精液质量参数之间的负相关可能表明，内分泌干扰化合物可通过降低精子数量和质量导致生殖问题。本研究将有助于评估人类对内分泌干扰化合物的暴露情况。
