Choi Jaeyeon, Eom Jinhee, Kim Jiye, Lee Sanghouck, Kim Yunje
Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea; Department of Chemistry, Interdisciplinary Program of Integrated Biotechnology, Sogang University, Shinsoo-dong, Mapo-gu, Seoul 121-742, Republic of Korea.
Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
Environ Toxicol Pharmacol. 2014 Jul;38(1):51-7. doi: 10.1016/j.etap.2014.04.004. Epub 2014 Apr 12.
Childhood obesity, a major public health concern, has increased worldwide. Endocrine-disrupting chemicals (EDCs) have recently received attention as a cause of obesity. A cross-sectional study using logistic regression was conducted to investigate the association between some endocrine disrupting chemicals and obesity in young girls. Endogenous steroids expected to be associated with EDCs were also investigated. The target compounds included 7 phthalates (MEP, DBP, MBP, DEHP, MEHP, PA and MBzP), 2 alkylphenols (4-NP and t-OP), bisphenol A and 9 endogenous steroids (DHT, epi-T, T, DHEA, A, P, E1, E2 and E3). PA in urine and MEP, DBP and PA in serum showed statistically significant differences between the control and obese groups, those compounds were considered to be associated with obesity. In addition, DHEA in serum showed a statistically significant difference between obese and control groups. We concluded that these substances can affect the development of obesity.
儿童肥胖是一个主要的公共卫生问题，在全球范围内呈上升趋势。内分泌干扰化学物质（EDCs）最近作为肥胖的一个成因受到关注。开展了一项使用逻辑回归的横断面研究，以调查某些内分泌干扰化学物质与年轻女孩肥胖之间的关联。还对预期与EDCs相关的内源性类固醇进行了研究。目标化合物包括7种邻苯二甲酸盐（MEP、DBP、MBP、DEHP、MEHP、PA和MBzP）、2种烷基酚（4-NP和t-OP）、双酚A以及9种内源性类固醇（双氢睾酮、表睾酮、睾酮、脱氢表雄酮、雄烯二酮、孕酮、雌酮、雌二醇和雌三醇）。尿液中的PA以及血清中的MEP、DBP和PA在对照组和肥胖组之间显示出统计学上的显著差异，这些化合物被认为与肥胖有关。此外，血清中的脱氢表雄酮在肥胖组和对照组之间也显示出统计学上的显著差异。我们得出结论，这些物质会影响肥胖的发展。
