Korea Institute of Science and Technology, Seongbuk-gu, Seoul, Republic of Korea.
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(13):2173-9. doi: 10.1080/10934529.2012.680387.
Hypospadias is a birth defect found in boys in which the urinary tract opening is not at the tip of the penis. The etiology of hypospadias is still unidentified, but endocrine disruptors are considered as one possible cause of hypospadias. In this study, target endocrine disruptor compounds were established for an assay. The target compounds included 5 phthalates (di-(2-ethylhexyl)phthalate (DEHP), di-n-butyl-phthalate (DBP), mono-(2- ethylhexyl) phthalate (MEHP), mono-n-butyl-phthalate (MBP) and phthalic acid (PA)), 2 alkylphenols (n-nonylphenol (n-NP) and t-octylphenol (t-OP)) and bisphenol A. The association between these 8 endocrine disruptors and hypospadias was studied. The levels of endocrine disruptors in the urine and plasma of a control group were compared with those of a patient group. DEHP (P = 0.006) and n-NP (P = 7.26e-6) in the urine samples and PA (P = 0.009) and BPA (P = 7.22e-10) in the plasma samples showed a significant association with hypospadias. The levels of endocrine disruptors in the urine and plasma of the mothers were also compared to those of the patients to investigate the metastasis of the endocrine disruptors from the mother. These levels did not, however, show a relationship with hypospadias (R(2) = 0.001-0.563).
尿道下裂是一种男孩的先天缺陷，其尿道开口不在阴茎的顶端。尿道下裂的病因仍不清楚，但内分泌干扰物被认为是尿道下裂的一个可能原因。在这项研究中，建立了针对测定的目标内分泌干扰物化合物。目标化合物包括 5 种邻苯二甲酸酯（邻苯二甲酸二（2-乙基己基）酯（DEHP）、邻苯二甲酸二正丁酯（DBP）、邻苯二甲酸单（2-乙基己基）酯（MEHP）、邻苯二甲酸单正丁酯（MBP）和邻苯二甲酸（PA））、2 种烷基酚（壬基酚（n-NP）和辛基酚（t-OP））和双酚 A。研究了这 8 种内分泌干扰物与尿道下裂之间的关系。将对照组和患者组的尿液和血浆中的内分泌干扰物水平进行了比较。尿液样本中的 DEHP（P = 0.006）和 n-NP（P = 7.26e-6）以及血浆样本中的 PA（P = 0.009）和 BPA（P = 7.22e-10）与尿道下裂呈显著相关。还比较了母亲尿液和血浆中的内分泌干扰物水平与患者的水平，以研究内分泌干扰物从母亲转移的情况。然而，这些水平与尿道下裂没有关系（R²= 0.001-0.563）。
