Xie Zhiwei, Zhang Yi, Liu Li, Weng Hong, Mason Ralph P, Tang Liping, Nguyen Kytai T, Hsieh Jer-Tsong, Yang Jian
Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
Adv Mater. 2014 Jul 9;26(26):4491-6. doi: 10.1002/adma.201306070. Epub 2014 Mar 26.
A method of introducing intrinsically photo luminescent properties to biodegradable polymer is introduced, exemplified by the synthesis of intrinsically photoluminescent polylactones that enable non-invasive monitoring and tracking of material degradation in vivo in realtime, as well as the formation of theranostic nanoparticles for cancer imaging and drug delivery.
介绍了一种将本征光致发光特性引入可生物降解聚合物的方法,以本征光致发光聚内酯的合成为例,该聚内酯能够实时、非侵入性地监测和跟踪体内材料的降解,以及用于癌症成像和药物递送的治疗诊断纳米颗粒的形成。