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现代放射治疗在早期霍奇金淋巴瘤中的作用:一位年轻放射肿瘤学家的观点。

Role of modern radiation therapy in early stage Hodgkin's lymphoma: A young radiation oncologists' perspective.

作者信息

Filippi Andrea Riccardo, Franco Pierfrancesco, Ciammella Patrizia

机构信息

Radiation Oncology, Department of Oncology, University of Torino, Torino, Italy.

Radiation Oncology Department, Tomotherapy Unit, Ospedale Regionale 'U. Parini', AUSL Valle d'Aosta, Aosta, Italy.

出版信息

Rep Pract Oncol Radiother. 2012 Jul 19;17(5):246-50. doi: 10.1016/j.rpor.2012.05.003. eCollection 2012 Sep.

DOI:10.1016/j.rpor.2012.05.003
PMID:24669302
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3885894/
Abstract

The role of radiotherapy is well established in combined modality programs for early stage Hodgkin's lymphoma, but still debated with regards to late toxicity issues. Modern radiotherapy prescribing attitudes include lower doses and smaller fields, together with the implementation of sophisticated and dedicated delivery techniques. Aim of this review is to briefly discuss the current role of radiotherapy in this field and the potential future developments. Major trials conducted in recent years in early stage Hodgkin's lymphoma are critically reviewed and discussed with a focus on radiotherapy-related issues and with an attention to current treatment options by a "young" radiation oncologists' perspective.

摘要

放射治疗在早期霍奇金淋巴瘤的综合治疗方案中的作用已得到充分确立,但在晚期毒性问题方面仍存在争议。现代放射治疗的处方理念包括降低剂量、缩小照射野,同时采用先进且专门的放疗技术。本综述的目的是简要讨论放射治疗在该领域的当前作用以及未来可能的发展。对近年来早期霍奇金淋巴瘤进行的主要试验进行了批判性回顾和讨论,重点关注与放射治疗相关的问题,并从一位“年轻”放射肿瘤学家的角度关注当前的治疗选择。

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本文引用的文献

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Cyberknife: A double edged sword?射波刀:一把双刃剑?
Rep Pract Oncol Radiother. 2010 Jul 6;15(4):93-7. doi: 10.1016/j.rpor.2010.05.002.
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ABVD alone versus radiation-based therapy in limited-stage Hodgkin's lymphoma.ABVD 方案单用与放疗在局限期霍奇金淋巴瘤中的比较。
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Ann Oncol. 2012 May;23(5):1259-1266. doi: 10.1093/annonc/mdr439. Epub 2011 Oct 6.
6
Hodgkin's lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.霍奇金淋巴瘤:ESMO诊断、治疗及随访临床实践指南
Ann Oncol. 2011 Sep;22 Suppl 6:vi55-8. doi: 10.1093/annonc/mdr378.
7
Involved-node radiotherapy and modern radiation treatment techniques in patients with Hodgkin lymphoma.累及野放疗和现代放疗技术在霍奇金淋巴瘤患者中的应用。
Int J Radiat Oncol Biol Phys. 2011 May 1;80(1):199-205. doi: 10.1016/j.ijrobp.2010.09.007.
8
Chemotherapy alone versus chemotherapy plus radiotherapy for early stage Hodgkin lymphoma.早期霍奇金淋巴瘤单纯化疗与化疗联合放疗的比较
Cochrane Database Syst Rev. 2011 Feb 16(2):CD007110. doi: 10.1002/14651858.CD007110.pub2.
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Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma.早期霍奇金淋巴瘤患者的治疗强度降低。
N Engl J Med. 2010 Aug 12;363(7):640-52. doi: 10.1056/NEJMoa1000067.
10
Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavorable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial.强化化疗联合受累野剂量降低放疗治疗早期不良预后霍奇金淋巴瘤患者:德国霍奇金研究组 HD11 试验的最终分析。
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