Skórska Małgorzata
Department of Medical Physics, Greater Poland Cancer Centre, Poznan, Poland.
Rep Pract Oncol Radiother. 2013 Jul 19;19(2):109-13. doi: 10.1016/j.rpor.2013.06.003. eCollection 2014 Mar.
A literature review was undertaken to identify current TSEB therapy in pediatric patients.
Total skin electron beam (TSEB) therapy is a method of irradiation with low energy electron beam dedicated to patients who have superficial skin lesions all over their body. Such skin malignancies are sparse among adults and even more uncommon with pediatric population.
In this study, all reported case reports were summed up with a special emphasis on techniques used, doses prescribed and special shielding of critical organs. Moreover, potential problems that were encountered during TSEB irradiation of very young patients were depicted.
The literature has described only seven case reports of children undergoing TSEB therapy. Most of them were infants; however, two adolescents were also treated. For all infants, general anesthesia was provided to allow safe and accurate TSEB irradiation. The prescribed dose varied from 16 Gy to 28 Gy depending on the irradiation schedule and patient condition. Usually, boost fields were applied to the scalp and perineum. Typical shields for fingernails, toenails and lenses were usually used.
This paper revealed that TSEB therapy may be considered as a palliative treatment for pediatric patients with leukemia cutis. However, its role is still unclear and should be further investigated.
进行文献综述以确定目前儿科患者的全身皮肤电子束（TSEB）治疗情况。
全身皮肤电子束治疗是一种用低能电子束进行照射的方法，适用于全身患有浅表皮肤病变的患者。此类皮肤恶性肿瘤在成人中较为少见，在儿科人群中更为罕见。
在本研究中，汇总了所有已报道的病例报告，特别强调了所使用的技术、规定剂量以及关键器官的特殊屏蔽。此外，还描述了在对非常年幼的患者进行TSEB照射过程中遇到的潜在问题。
文献中仅描述了7例接受TSEB治疗的儿童病例报告。其中大多数是婴儿；不过，也有两名青少年接受了治疗。对于所有婴儿，均提供全身麻醉以确保安全、准确地进行TSEB照射。规定剂量根据照射方案和患者情况在16 Gy至28 Gy之间变化。通常，对头 皮和会阴施加加量照射野。通常会使用针对指甲、趾甲和晶状体的典型屏蔽。
本文表明，TSEB治疗可被视为儿童皮肤白血病患者的一种姑息治疗方法。然而，其作用仍不明确，应进一步研究。
