Gadhwal Ajeet Kumar, Ankit B S, Chahar Chitresh, Tantia Pankaj, Sirohi P, Agrawal R P
Sr. Registrar.
Sr. Resident.
J Assoc Physicians India. 2016 Jun;64(6):22-26.
Thrombocytopenia in dengue fever is a common and serious complication. However, no specific treatment is available for dengue fever induced thrombocytopenia. In few countries (Pakistan, Malaysia, Sri Lanka and other Asian countries) the leaf extract of Carica papaya has been effectively used for thrombocytopenia. So, the study is planned to access effect of Carica papaya leaf extract on platelet count in dengue fever patients.
All participants were randomised into two groups, study group and control group; the study group was given papaya leaf extract capsule of 500 mg once daily and routine supportive treatment for consecutive five days. The controls were given only routine supportive treatment. Daily complete blood counts, platelet counts and haematocrit level, liver function test, renal function test of both groups were observed.
On the first day platelet count of study group and control group was (59.82±18.63, 61.06±20.03 thousands, p value 0.36). On the 2nd day platelet count of both study and control groups was not significantly different (61.67±19.46 and 59.93±19.52 thousands, p value 0.20) but on 3rd day platelet count of study group was significantly higher than control group (82.96±16.72, 66.45±17.36 thousands, p value < 0.01). On 4th and 5th day platelet count of study group (122.43±19.36 and 112.47±17.49 thousands respectively) was also significantly higher than the control group (88.75±21.65 and 102.59±19.35 thousands) (p value < 0.01). On 7th day platelet count of study group and control group were not significantly different (124.47±12.35 and 122.46±19.76 thousands respectively, p value 0.08). Average hospitalization period of study group v/s control group was 3.65±0.97 v/s 5.42±0.98 days (p value < 0.01). Average platelet transfusion requirement in study group was significantly less than control group (0.685 units per patient v/s 1.19 units per patient) (p value <0.01).
It is concluded that Carica papaya leaf extract increases the platelet count in dengue fever without any side effect and prevents the complication of thrombocytopenia. So, it can be used in dengue fever with thrombocytopenia patients.
登革热中的血小板减少是一种常见且严重的并发症。然而，对于登革热所致血小板减少尚无特效治疗方法。在少数国家（巴基斯坦、马来西亚、斯里兰卡及其他亚洲国家），番木瓜叶提取物已被有效用于治疗血小板减少。因此，本研究旨在探讨番木瓜叶提取物对登革热患者血小板计数的影响。
所有参与者被随机分为两组，即研究组和对照组；研究组给予500毫克番木瓜叶提取物胶囊，每日一次，连续五天，并给予常规支持治疗。对照组仅给予常规支持治疗。观察两组的每日全血细胞计数、血小板计数、血细胞比容水平、肝功能检查及肾功能检查。
第一天研究组和对照组的血小板计数分别为（59.82±18.63、61.06±20.03千，p值0.36）。第二天研究组和对照组的血小板计数无显著差异（分别为61.67±19.46和59.93±19.52千，p值0.20），但第三天研究组的血小板计数显著高于对照组（82.96±16.72、66.45±17.36千，p值<0.01）。第四天和第五天研究组的血小板计数（分别为122.43±19.36和112.47±17.49千）也显著高于对照组（88.75±21.65和102.59±19.35千）（p值<0.01）。第七天研究组和对照组的血小板计数无显著差异（分别为124.47±12.35和122.46±19.76千，p值0.08）。研究组与对照组的平均住院时间分别为3.65±0.97天和5.42±0.98天（p值<0.01）。研究组的平均血小板输注需求量显著低于对照组（每位患者0.685单位对每位患者1.19单位）（p值<0.01）。
得出结论，番木瓜叶提取物可增加登革热患者的血小板计数且无任何副作用，并预防血小板减少的并发症。因此，它可用于登革热伴血小板减少的患者。
