Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Cheras 56000, Kuala Lumpur, Malaysia.
Biomolecules. 2020 Dec 30;11(1):42. doi: 10.3390/biom11010042.
While dengue virus (DENV) infection imposes a serious challenge to the survival of humans worldwide, severe acute respiratory syndrome-coronavirus (SARS-CoV) remains the most devastating pandemic in human history. A significant number of studies have shown that plant-derived substances could serve as potential candidates for the development of safe and efficacious remedies for combating these diseases. Different scientific databases were used to source for literature on plants used against these infections. Thirty-five studies described the traditional use of 25 species from 20 families for treating DENV infection with and were the most widely used across different regions. 13 in vivo studies, 32 in vitro studies, and eight clinical studies were conducted on 30 species from 25 families against different DENV serotypes, while plants from 13 families were reported to inhibit different forms of SARS-CoV, all of which were investigated through in vitro studies. Phytoconstituents belonging to various chemical classes were identified to show a wide range of antiviral activity against these infections. Extensive studies on the potentials of medicinal plants are needed to confirm their efficacy. This paper reveals the capabilities of medicinal plants and their phytochemicals in inhibiting DENV and SARS-CoV infections.
虽然登革热病毒（DENV）感染对全球人类的生存构成了严重挑战，但严重急性呼吸综合征冠状病毒（SARS-CoV）仍然是人类历史上最具破坏性的大流行病。大量研究表明，植物衍生物质可以作为开发安全有效的治疗这些疾病的潜在候选物。使用不同的科学数据库来获取有关用于治疗这些感染的植物的文献。有 35 项研究描述了来自 20 个科的 25 种植物用于治疗 DENV 感染的传统用途， 和 在不同地区的使用最为广泛。针对不同 DENV 血清型，对 30 种来自 25 个科的 30 种植物进行了 13 项体内研究、32 项体外研究和 8 项临床研究，而来自 13 个科的植物被报道可以抑制不同形式的 SARS-CoV，所有这些都通过体外研究进行了调查。鉴定出属于各种化学类别的植物成分，以显示它们对这些感染具有广泛的抗病毒活性。需要对药用植物的潜力进行广泛研究，以确认其疗效。本文揭示了药用植物及其植物化学物质在抑制 DENV 和 SARS-CoV 感染方面的能力。
