Kunz Anna Lena, Labes Antje, Wiese Jutta, Bruhn Torsten, Bringmann Gerhard, Imhoff Johannes F
Kiel Center for Marine Natural Products at the Helmholtz Center for Ocean Research (GEOMAR), Am Kiel-Kanal 44, Kiel 24106, Germany.
Institute of Organic Chemistry, University of Wuerzburg, Am Hubland, Wuerzburg 97074, Germany.
Mar Drugs. 2014 Mar 25;12(4):1699-714. doi: 10.3390/md12041699.
Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I-K) also showed moderate activities against PDE 4B.
到目前为止，已鉴定出8种链吩嗪（A-H）是链霉菌菌株HB202的产物，该菌株是从波罗的海的海绵Halichondria panicea中分离出来的。基于微小结构变化的生物活性差异引发了对新衍生物的进一步研究。在本研究中，发酵后鉴定出3种新的链吩嗪（I-K）。此外，还提出了链吩嗪C、D、F和H的修订分子结构。链吩嗪G和K对兼性病原菌表皮葡萄球菌和枯草芽孢杆菌表现出中等抗菌活性。所有测试化合物（链吩嗪G、I-K）对PDE 4B也表现出中等活性。
