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本文引用的文献

1
Benchmarking outcomes in the critically injured burn patient.严重烧伤患者的基准测试结果。
Ann Surg. 2014 May;259(5):833-41. doi: 10.1097/SLA.0000000000000438.
2
Genomic responses in mouse models poorly mimic human inflammatory diseases.小鼠模型中的基因组反应与人类炎症性疾病的反应相差很大。
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12. doi: 10.1073/pnas.1222878110. Epub 2013 Feb 11.
3
The American Burn Association/Shriners Hospitals for Children Burn Outcomes Program: a progress report at 15 years.美国烧伤协会/施里纳儿童医院烧伤结果计划:15 年进展报告。
J Trauma Acute Care Surg. 2012 Sep;73(3 Suppl 2):S173-8. doi: 10.1097/TA.0b013e318265c53e.
4
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures.在危重伤患者中进行基准测试的结果以及实施标准操作程序的效果。
Ann Surg. 2012 May;255(5):993-9. doi: 10.1097/SLA.0b013e31824f1ebc.
5
A genomic storm in critically injured humans.危重症患者的基因组风暴。
J Exp Med. 2011 Dec 19;208(13):2581-90. doi: 10.1084/jem.20111354. Epub 2011 Nov 21.
6
METABOLIC OBSERVATIONS.代谢观察
Ann Surg. 1943 Jun;117(6):937-58.
7
A NOTE ON THE THROMBOPHLEBITIS ENCOUNTERED.关于所遇到的血栓性静脉炎的一则笔记。
Ann Surg. 1943 Jun;117(6):931-6. doi: 10.1097/00000658-194311760-00015.
8
A NOTE ON THE BLOOD BANK.关于血库的说明。
Ann Surg. 1943 Jun;117(6):928-31. doi: 10.1097/00000658-194306000-00014.
9
THE PROBLEM OF BURN SHOCK COMPLICATED BY PULMONARY DAMAGE.烧伤休克并发肺损伤的问题。
Ann Surg. 1943 Jun;117(6):915-28. doi: 10.1097/00000658-194306000-00013.
10
A NOTE ON PHYSICAL THERAPY.关于物理治疗的说明
Ann Surg. 1943 Jun;117(6):911-4. doi: 10.1097/00000658-194306000-00012.

新千年烧伤患者的生存情况:来自单一机构的70年经验。

Survival from burns in the new millennium: 70 years' experience from a single institution.

作者信息

Tompkins Ronald G

机构信息

From the Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA.

出版信息

Ann Surg. 2015 Feb;261(2):263-8. doi: 10.1097/SLA.0000000000000623.

DOI:10.1097/SLA.0000000000000623
PMID:24670865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4372065/
Abstract

OBJECTIVE

This review explores the series of published analyses from Massachusetts General Hospital to better understand how changes in medical specialization of burn medicine likely enabled the most important increase in survival from burns in the past 70 years.

BACKGROUND

Seventy years ago, survival from the most serious burn injuries was not possible even in the most advanced countries until critical advances were introduced. Insights into those few medical advances that actually impacted survival might be better understood from the consideration of a continuous series of survival analyses over 7 decades at Massachusetts General Hospital.

METHODS

Mortality data from previously reported probit and logit analyses from thousands of patients treated at Massachusetts General Hospital were reviewed. A comparison of mortality from these prior mortality analyses from a more recent multicenter study and a national data set was performed.

RESULTS

The only giant leap forward in survival occurred during the 1970s, with no improvement during either the preceding or subsequent 30-year intervals. Despite the many modern advances that have been added to the care of these patients since 1984, although these may have represented medical progress, these advances did not impact survival.

CONCLUSIONS

Survival rates from burn injury may have been maximized by current treatment approaches within medical centers of excellence in burn medicine. Further efforts to improve the quality of life of survivors of burn injury should ultimately have very favorable impact upon the long-term outcomes in these patients who now survive such devastating injuries.

摘要

目的

本综述探讨了麻省总医院发表的一系列分析,以更好地理解烧伤医学专业的变化如何可能促成了过去70年中烧伤存活率最重要的提升。

背景

70年前,即使在最先进的国家,除非引入关键进展,否则最严重的烧伤伤者也无法存活。通过考虑麻省总医院70多年来一系列连续的生存分析,或许能更好地理解那些真正影响存活率的医学进展。

方法

回顾了麻省总医院此前对数以千计患者进行的概率分析和逻辑分析中报告的死亡率数据。将这些先前死亡率分析的死亡率与最近的一项多中心研究和一个全国数据集进行了比较。

结果

存活率唯一的巨大飞跃发生在20世纪70年代,在之前和之后的30年期间均无改善。尽管自1984年以来,这些患者的护理增加了许多现代进展,尽管这些可能代表了医学进步,但这些进展并未影响存活率。

结论

在烧伤医学卓越中心,当前的治疗方法可能已使烧伤损伤的存活率最大化。进一步努力改善烧伤幸存者的生活质量,最终应会对这些如今在如此严重损伤中存活下来的患者的长期预后产生非常有利的影响。