奥洛珠单抗的发现与特性：一种靶向白细胞介素-6并中和gp130信号传导的人源化抗体

Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling.

作者信息

Shaw Stevan, Bourne Tim, Meier Chris, Carrington Bruce, Gelinas Rich, Henry Alistair, Popplewell Andrew, Adams Ralph, Baker Terry, Rapecki Steve, Marshall Diane, Moore Adrian, Neale Helen, Lawson Alastair

机构信息

UCB Pharma; Berkshire, UK.

Institute for Systems Biology; Seattle, WA USA.

出版信息

MAbs. 2014 May-Jun;6(3):774-82. doi: 10.4161/mabs.28612. Epub 2014 Apr 2.

Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease. Here, we describe the discovery and characterization of olokizumab, a humanized antibody to IL-6. Data from structural biology, cell biology and primate pharmacology demonstrate the therapeutic potential of targeting IL-6 at "Site 3", blocking the interaction with the signaling co-receptor gp130.