温和刺激会成为当下的主流吗？
Should mild stimulation be the order of the day?
作者信息
Mahajan Nalini
机构信息
Department of Reproductive Medicine, NOVA IVI Fertility, New Delhi, India.
出版信息
J Hum Reprod Sci. 2013 Oct;6(4):220-6. doi: 10.4103/0974-1208.126282.
Abstract
Mild stimulation protocols aim to reduce the physical, financial and emotional burden associated with the conventional IVF protocol without compromising the pregnancy rate. Such protocols help to decrease the complications and the discomfort related to the prolonged administration of agonist and large doses of gonadotrophins, by limiting the number of oocytes recruited to no more than eight. The per cycle pregnancy rates are lower though the cumulative pregnancy rate in a year is equivalent. This CPR comes by going through earlier repeat cycles. Whether this reduces the physical, emotional or financial burden remains a matter of debate. There is need to standardize these protocol and do more trials to compare the two effectively. Till such time there is a clear benefit above the conventional protocol it will not be the protocol of choice with most physicians.
摘要
温和刺激方案旨在减轻与传统体外受精方案相关的身体、经济和情感负担，同时不影响妊娠率。此类方案通过将募集的卵母细胞数量限制在不超过8个，有助于减少与长期使用激动剂和大剂量促性腺激素相关的并发症和不适。尽管每年的累积妊娠率相当，但每个周期的妊娠率较低。这种累积妊娠率是通过更早地进行重复周期实现的。这是否减轻了身体、情感或经济负担仍存在争议。需要对这些方案进行标准化，并开展更多试验以有效比较两者。在明确显示出比传统方案有明显益处之前，大多数医生不会选择该方案。
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