Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan 8187698191, Iran.
Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, P.O. Box 81465-1148, Isfahan 8187698191, Iran.
Int J Endocrinol. 2014;2014:203463. doi: 10.1155/2014/203463. Epub 2014 Feb 5.
Background. Metabolic syndrome (MetS) and psychological distress are hypothesized to have a bidirectional relationship. According to their high prevalence in most populations, appraisal of this theory would be of great clinical and research interest. Methods. Data were available as part of the Isfahan Healthy Heart Program (IHHP). A total of 9553 men and women aged ≥19 years from three counties in central Iran were selected. Measurements consisted of serologic tests, anthropometrics, and self-reported 12-item general health questionnaire. Logistic regression analysis was used to find the association between MetS, MetS components, and distress level. Results. The mean age of 9553 participants (50% male) was 38.7 ± 15.8 years. After adjusting for demographic factors, MetS (OR = 1.25, 95% CI: 1.01-1.37), central obesity (OR = 1.40, 95% CI: 1.15-1.49), and hypertension (OR = 1.55, 95% CI: 1.42-1.70) were associated with high distress level. However, after adding smoking status and low-density lipoprotein cholesterol to the adjustment factors, hypertension (OR = 1.79, 95% CI: 1.53-1.98) and central obesity (OR = 1.41, 95% CI: 1.17-1.55), but not the MetS, remained significantly associated with distress level. Conclusion. The presence of association between the MetS as well as its key components and high distress level signifies the importance of integrating psychological assessment and intervention in the standard management of MetS patients.
代谢综合征（MetS）和心理困扰被认为存在双向关系。鉴于它们在大多数人群中的高患病率，评估这一理论将具有重要的临床和研究意义。方法：数据来自伊朗中部三个县的伊斯法罕健康心脏计划（IHHP）。共选取了 9553 名年龄≥19 岁的男性和女性。测量包括血清学检查、人体测量学和自我报告的 12 项一般健康问卷。使用逻辑回归分析来发现 MetS、MetS 成分和困扰水平之间的关联。结果：9553 名参与者（50%为男性）的平均年龄为 38.7±15.8 岁。在调整人口统计学因素后，MetS（OR=1.25，95%CI：1.01-1.37）、中心性肥胖（OR=1.40，95%CI：1.15-1.49）和高血压（OR=1.55，95%CI：1.42-1.70）与高困扰水平相关。然而，在将吸烟状况和低密度脂蛋白胆固醇添加到调整因素中后，高血压（OR=1.79，95%CI：1.53-1.98）和中心性肥胖（OR=1.41，95%CI：1.17-1.55），而不是 MetS，与困扰水平仍存在显著关联。结论：MetS 及其关键成分与高困扰水平之间存在关联，这表明在 MetS 患者的标准管理中整合心理评估和干预的重要性。
