Nikolaevich K N, Ivanovich S J, Victorovich S S
Department of Biochemistry, Perm Medical Institute, USSR.
Brain Behav Immun. 1991 Jun;5(2):149-61. doi: 10.1016/0889-1591(91)90013-z.
The effects of chorionic gonadotropin (CG), estradiol, and progesterone on the cell mechanisms that determine the rate of the humoral immune response have been investigated in experiments on ovariectomized and noncastrated mice. CG (40 IU) injected into noncastrated animals increased the antibody response to sheep erythrocytes (SRBC), whereas a higher dose of the hormone (200 IU) had no effect. In contrast, both hormone doses inhibited the immune response in ovariectomized animals. Injection of estradiol (2.5 micrograms/day), but not progesterone (0.2 mg/day), into ovariectomized mice stimulated the immune response, indicating a possible role of estrogens as mediators of CG immuno-stimulating effect in noncastrated animals. Both CG does inhibited suppressor cell generation in noncastrated mice, whereas in ovariectomized animals, the hormonal effect was directly opposite. Sex steroid hormones did not influence the formation of suppressor cells. In a syngeneic transfer system, the hormones under study did not change the activity of helper T cell precursors. However, CG administration to noncastrated recipients stimulated an adoptive immune response in a dose-dependent manner. Estradiol, but not progesterone, has the same effect in ovariectomized mice. CG administration (200 IU) to ovariectomized recipients inhibited the plaque-forming cell response. This CG effect depended upon prostaglandin synthetase activity.
在对去卵巢和未去势小鼠进行的实验中，研究了绒毛膜促性腺激素（CG）、雌二醇和孕酮对决定体液免疫反应速率的细胞机制的影响。给未去势动物注射40国际单位的CG可增强对绵羊红细胞（SRBC）的抗体反应，而更高剂量的该激素（200国际单位）则无此作用。相比之下，这两种激素剂量均抑制去卵巢动物的免疫反应。给去卵巢小鼠注射雌二醇（2.5微克/天）而非孕酮（0.2毫克/天）可刺激免疫反应，这表明雌激素可能作为未去势动物中CG免疫刺激作用的介质。两种剂量的CG均抑制未去势小鼠中抑制性细胞的生成，而在去卵巢动物中，激素作用则正好相反。性类固醇激素不影响抑制性细胞的形成。在同基因转移系统中，所研究的激素不会改变辅助性T细胞前体的活性。然而，给未去势受体注射CG可剂量依赖性地刺激过继免疫反应。在去卵巢小鼠中，雌二醇而非孕酮具有相同的作用。给去卵巢受体注射200国际单位的CG可抑制空斑形成细胞反应。这种CG效应取决于前列腺素合成酶的活性。
