Rauf Abdur, Khan Rehan, Khan Haroon, Pervez Samreen, Pirzada Abdul Saboor
a Institute of Chemical Sciences, University of Peshawar , Peshawar - 25120 , KPK , Pakistan.
Nat Prod Res. 2014;28(17):1371-4. doi: 10.1080/14786419.2014.901317. Epub 2014 Mar 28.
This study was designed to evaluate the antinociceptive and anti-inflammatory activities of a compound, umbelliferone, isolated from the chloroform fraction of Potentilla evestita in animal models. When tested against acetic acid-induced noxious stimulus, it significantly prolonged pain threshold and provided 38.38% and 60.95% reduction in abdominal constriction at 5 and 10 mg/kg i.p., respectively. Post-umbelliferone injection evoked significant dose-dependent reduction in noxious stimulation with 33.65% and 58.89% pain attenuation at 5 and 10 mg/kg i.p., respectively, in the initial phase. In the late phase, it illustrated more dominant effect with 37.65% and 63.79% blockade of painful sensation. Similarly, it exhibited significant anti-inflammatory activity during various assessment times (1-5 h) with 46.28% and 66.13% amelioration after 4th of administration against induced oedema. In conclusion, umbelliferone possessed strong antinociceptive and anti-inflammatory activities by inhibiting both peripheral and centrally acting pain mediators.
本研究旨在评估从委陵菜氯仿提取物中分离出的化合物伞形花内酯在动物模型中的抗伤害感受和抗炎活性。在针对醋酸诱导的伤害性刺激进行测试时，它显著延长了疼痛阈值，腹腔注射5和10mg/kg时，腹部收缩分别减少了38.38%和60.95%。注射伞形花内酯后，在初始阶段，腹腔注射5和10mg/kg时，伤害性刺激显著剂量依赖性降低，疼痛减轻分别为33.65%和58.89%。在后期，它表现出更显著的效果，疼痛感觉阻断率分别为37.65%和63.79%。同样，在不同评估时间（1-5小时），它都表现出显著的抗炎活性，给药后第4小时对诱导性水肿的改善率分别为46.28%和66.13%。总之，伞形花内酯通过抑制外周和中枢作用的疼痛介质，具有强大的抗伤害感受和抗炎活性。
