钯催化丙烯酸和酰胺与炔烃的氧化环化反应：合成α-吡喃酮和吡啶酮的实用路线。
Palladium-catalyzed oxidative annulation of acrylic acid and amide with alkynes: a practical route to synthesize α-pyrones and pyridones.
机构信息
School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
出版信息
Org Lett. 2014 Apr 18;16(8):2146-9. doi: 10.1021/ol500611d. Epub 2014 Mar 27.
PMID:24673501
Abstract
A range of internal alkynes smoothly underwent palladium-catalyzed oxidative annulations with acrylic acid and amide to afford α-pyrones and pyridones in good to excellent yields with high regioselectivity. The usage of O2 (1 atm) as a stoichiometric oxidant with H2O as the only byproduct under mild conditions makes this process more attractive and practical.
摘要
一系列内炔烃在钯催化下与丙烯酸和酰胺发生氧化环化反应，以良好至优异的收率和高区域选择性得到α-吡喃酮和吡啶酮。使用 O2（1 atm）作为化学计量氧化剂，H2O 作为唯一的副产物，在温和条件下进行反应，使该过程更具吸引力和实用性。
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