Department of Clinical and Molecular Medicine, Sapienza University of Rome, Italy.
GENOMA Molecular Genetics Laboratory, Rome, Italy.
Int J Immunopathol Pharmacol. 2014 Jan-Mar;27(1):143-6. doi: 10.1177/039463201402700120.
The yeast Saccharomyces boulardii is a biotherapeutic agent used for the prevention and treatment of several gastrointestinal diseases, such as diarrhoea caused by Clostridium difficile, in addition to the antibiotic therapy. In this study we report a case of Saccharomyces cerevisiae fungemia in a patient with Clostridium difficile-associated diarrhoea (CDAD) treated orally with S. boulardii in association with vancomycin. The identification of the S. cerevisiae was confirmed by molecular technique. Fungemia is a rare, but a serious complication to treatment with probiotics. We believe it is important to remind the clinicians of this risk when prescribing probiotics, especially to immunocompromised patients.
酵母布拉氏酵母菌是一种生物治疗剂，用于预防和治疗多种胃肠道疾病，例如艰难梭菌引起的腹泻，此外还可与抗生素治疗联合使用。在本研究中，我们报告了一例艰难梭菌相关性腹泻（CDAD）患者在口服布拉氏酵母菌联合万古霉素治疗过程中发生的酵母属念珠菌血症。通过分子技术确认了念珠菌属的存在。念珠菌血症是一种罕见但严重的益生菌治疗并发症。我们认为，当开具益生菌处方时，临床医生应注意这种风险，特别是对于免疫功能低下的患者。
