Vandborg Sanne Kjær, Hartmann Tue Borst, Bennedsen Birgit Egedal, Pedersen Anders Degn, Thomsen Per Hove
*Clinic for OCD and Anxiety Disorders †Center for Psychiatric Research §Regional Center for Child and Adolescent Psychiatry, Aarhus University Hospital Risskov, Risskov, Denmark ‡Vejlefjord Rehabilitation, Stouby, Denmark.
Cogn Behav Neurol. 2014 Mar;27(1):8-16. doi: 10.1097/WNN.0000000000000021.
We investigated whether patients with obsessive-compulsive disorder have poorer memory and executive functions than healthy controls.
The relatively inconsistent previous findings on this question reflect a lack of well-matched control groups, the inclusion of patients with comorbidity, and the use of noncomparable neuropsychological tests to assess memory and executive functions.
We used well-accepted neuropsychological tests of memory and executive functions to assess 42 patients who had obsessive-compulsive disorder without comorbidity, and 42 healthy controls. We matched the patients and controls pairwise by sex, age, and years of education.
The patients performed significantly worse than the controls on the Rey Complex Figure Test, which assesses visuospatial memory and organizational skills. This group difference remained after we controlled for age, education, intelligence, and severity of depressive symptoms.
The findings indicate that patients with obsessive-compulsive disorder may have impaired visuospatial memory and organizational skills, and these impairments should be considered in treatment.
ClinicalTrials.gov NCT00792038.
我们调查了强迫症患者的记忆和执行功能是否比健康对照者更差。
此前关于这个问题的研究结果相对不一致，这反映出缺乏匹配良好的对照组、纳入了合并其他疾病的患者，以及使用了不可比的神经心理学测试来评估记忆和执行功能。
我们使用广泛认可的记忆和执行功能神经心理学测试，对42名无合并症的强迫症患者和42名健康对照者进行评估。我们根据性别、年龄和受教育年限对患者和对照者进行配对。
在评估视觉空间记忆和组织技能的雷氏复杂图形测验中，患者的表现显著差于对照者。在我们控制了年龄、教育程度、智力和抑郁症状严重程度后，这种组间差异依然存在。
研究结果表明，强迫症患者可能存在视觉空间记忆和组织技能受损的情况，在治疗中应考虑这些损害。
ClinicalTrials.gov NCT00792038。
