Belcaro G, Luzzi R, Dugall M, Ippolito E, Saggino A
Department of Biomedical Sciences Chieti, Pescara University, Irvine3 Labs, Pescara, Italy -
J Neurosurg Sci. 2014 Dec;58(4):239-48. Epub 2014 Mar 28.
This 12-week, product-evaluation registry study aimed to compare the effects of supplementation with French Pine Bark Extract (Pycnogenol®) on cognitive function, attention, and mental performance in healthy professionals with increased oxidative stress in a professional context.
Professionals were screened for increased oxidative stress: 60 subjects (range 35-55 years, no risk conditions, no addictions) voluntarily decided to be followed-up. Diet, alcohol and lifestyle patterns, including exercise, were controlled. Pycnogenol® (150 mg/day) was used in combination with a health plan to enhance mental performance and control oxidative stress.
A group of 30 professionals used Pycnogenol®, and 29 acted as comparable controls for a period of 12 weeks. The two registry groups were comparable. Cognitive function, attention, mental performance, sustained attention, memory, executive functions, mood and oxidative stress values were comparable at inclusion. At 12 weeks the improvement in Pycnogenol® subjects was more significant than in controls. Plasma-free radicals (oxidative stress) were significantly decreased (median -30.4%) at 12 weeks in Pycnogenol® subjects in comparison with a non-significant variation observed in controls (+0.9%; difference between groups). Considering the cognitive test battery (PASAT, pattern recognition memory, spatial recognition memory, spatial working memory), Pycnogenol® subjects showed a small but significant improvement with spatial recognition memory unchanged. Mood parameters (alertness, anxiety, contentedness) also improved in professionals using the supplement. In the evaluation of 12 professional daily tasks all items were improved with Pycnogenol® supplementation. The score relative to semi-professional minitasks was improved more in Pycnogenol® subjects. Tolerability and compliance were optimal with >94% of the doses of supplement correctly used.
Pycnogenol® supplementation for 12 weeks appears to improve cognitive function and oxidative stress in healthy professionals.
这项为期12周的产品评估注册研究旨在比较补充法国松树皮提取物（碧萝芷®）对在职业环境中氧化应激增加的健康专业人员的认知功能、注意力和心理表现的影响。
对专业人员进行氧化应激增加的筛查：60名受试者（年龄范围35 - 55岁，无风险状况，无成瘾问题）自愿决定接受随访。对饮食、酒精和生活方式模式，包括运动进行了控制。碧萝芷®（150毫克/天）与一项健康计划联合使用，以提高心理表现并控制氧化应激。
一组30名专业人员使用碧萝芷®，29名作为对照，为期12周。两个注册组具有可比性。纳入时，认知功能、注意力、心理表现、持续注意力、记忆力、执行功能、情绪和氧化应激值具有可比性。在12周时，服用碧萝芷®的受试者的改善比对照组更显著。与对照组观察到的无显著变化（+0.9%；组间差异）相比，服用碧萝芷®的受试者在12周时血浆自由基（氧化应激）显著降低（中位数 - 30.4%）。考虑认知测试组合（PASAT、模式识别记忆、空间识别记忆、空间工作记忆），服用碧萝芷®的受试者在空间识别记忆不变的情况下有小幅但显著的改善。使用该补充剂的专业人员的情绪参数（警觉性、焦虑、满足感）也有所改善。在对12项专业日常任务的评估中，补充碧萝芷®后所有项目均有改善。服用碧萝芷®的受试者相对于半专业小任务的得分改善更大。耐受性和依从性最佳，超过94%的补充剂剂量被正确使用。
补充碧萝芷®12周似乎可改善健康专业人员的认知功能和氧化应激。
