Simpson Tamara, Kure Christina, Stough Con
Swinburne Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC, Australia.
Front Pharmacol. 2019 Jul 3;10:694. doi: 10.3389/fphar.2019.00694. eCollection 2019.
Brain aging is a complex and multifactorial process broadly involving changes in the brain's structure, neuronal activity, and biochemical profile. These changes in brain function have also been linked to age-associated variations in cognitive function. Recent research has suggested a role of increased oxidative stress and reduced cognition in older people. Therefore, studies that examine the effects of antioxidants on cognitive performance are important, particularly in the context of an increase in elderly populations in most Western countries. One such antioxidant, Pycnogenol, is a standardized plant-based extract obtained from the bark of the French maritime pine and has a long historical use to treat inflammation and improve health. More recently, Pycnogenol has been subjected to more than 100 research trials. and animal studies using the standardized extract have indicated a multimodal action of Pycnogenol, and several human studies have shown improvements in cognitive function after chronic administration. In this paper, we review these studies in the context of understanding both biological and cognitive changes due to Pycnogenol and evaluate possibilities of Pycnogenol to improve neurocognitive function.
大脑衰老过程复杂且受多种因素影响，广泛涉及大脑结构、神经元活动和生化特征的变化。大脑功能的这些变化也与认知功能的年龄相关差异有关。最近的研究表明，氧化应激增加与老年人认知能力下降有关。因此，研究抗氧化剂对认知表现的影响非常重要，尤其是在大多数西方国家老年人口增加的背景下。其中一种抗氧化剂碧萝芷是从法国滨海松树皮中提取的标准化植物提取物，长期以来一直用于治疗炎症和改善健康。最近，碧萝芷已经接受了100多项研究试验。使用该标准化提取物的动物研究表明碧萝芷具有多模式作用，多项人体研究表明长期服用后认知功能有所改善。在本文中，我们在理解碧萝芷引起的生物学和认知变化的背景下回顾这些研究，并评估碧萝芷改善神经认知功能的可能性。
