细胞周期蛋白和细胞周期依赖性激酶在多能干细胞中的作用及其作为治疗靶点的潜力。
Role of cyclins and cyclin-dependent kinases in pluripotent stem cells and their potential as a therapeutic target.
机构信息
Siriraj Center of Research for Excellence for Systems Pharmacology, Department of Pharmacology, Faculty of Medicine, Siriraj Medical School, Mahidol University, Bangkok, 10700, Thailand.
Center for Molecular Medicine and Department of Biochemistry and Molecular Biology, 325 Riverbend Road, The University of Georgia, Athens, GA, 30602, USA.
出版信息
Semin Cell Dev Biol. 2020 Nov;107:63-71. doi: 10.1016/j.semcdb.2020.05.001. Epub 2020 May 14.
Abstract
Over the last 15 years connections between cell cycle control, maintenance of pluripotency, and control of cell fate decisions have been firmly established. With the emergence of powerful tools, such as highly-specific small molecule inhibitors for cyclin-dependent protein kinase (CDK) activity and single-cell imaging technologies, the mechanistic links between cyclins, CDKs and regulation in PSCs in mechanistic detail has been made possible. In this review, we discuss new developments that mechanistically link the CDK regulatory network to control of cell fate decisions, including maintenance of the pluripotent state. Overall, these findings have potential to impact the translational applications of stem cells in regenerative medicine, drug discovery and cancer treatment.
摘要
在过去的 15 年中，细胞周期调控、多能性维持和细胞命运决定控制之间的联系已经得到了充分的证实。随着强大工具的出现，如高度特异性的细胞周期蛋白依赖性激酶（CDK）活性小分子抑制剂和单细胞成像技术，使我们能够以机械细节的方式了解多能干细胞中细胞周期蛋白、CDK 和调控之间的机制联系。在这篇综述中，我们讨论了将 CDK 调控网络与细胞命运决定控制，包括多能性维持，联系起来的新发现。总的来说，这些发现有可能影响干细胞在再生医学、药物发现和癌症治疗中的转化应用。
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