Kawano Takashi, Takahashi Tetsuya, Iwata Hideki, Morikawa Akihiro, Imori Satoko, Waki Sayaka, Tamura Takahiko, Yamazaki Fumimoto, Eguchi Satoru, Kumagai Naoko, Yokoyama Masataka
Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan,
J Anesth. 2014 Dec;28(6):932-6. doi: 10.1007/s00540-014-1821-y. Epub 2014 Mar 28.
Postoperative cognitive dysfunction is a common geriatric complication that may be associated with increased mortality. Here, we investigated the effects of postoperative analgesia with ketoprofen on cognitive functions in aged animals and compared its effectiveness to morphine. Rats were randomly allocated to one of four groups: isoflurane anesthesia without surgery (group C), isoflurane anesthesia with laparotomy (group IL), and isoflurane anesthesia with laparotomy plus postoperative analgesia with ketoprofen or morphine. There was no difference in postoperative locomotor activity among groups. In group IL, postoperative pain levels assessed by the Rat Grimace Scale significantly increased until 8 h after surgery, which was similarly inhibited by both ketoprofen and morphine. Cognitive function was assessed using radial arm maze testing for 12 consecutive days from postoperative day 3. Results showed that the number of memory errors in group IL were significantly higher than those in goup C. However, both ketoprofen and morphine could attenuate the increase in memory errors following surgery to a similar degree. Conversely, ketoprofen showed no effect on cognitive function in the nonsurgical rats that did not experience pain. Our findings suggest that postoperative analgesia with ketoprofen can prevent the development of surgery-associated memory deficits via its pain-relieving effects.
术后认知功能障碍是一种常见的老年并发症，可能与死亡率增加有关。在此，我们研究了酮洛芬术后镇痛对老年动物认知功能的影响，并将其有效性与吗啡进行比较。大鼠被随机分为四组之一：未进行手术的异氟烷麻醉组（C组）、接受剖腹手术的异氟烷麻醉组（IL组），以及接受剖腹手术加酮洛芬或吗啡术后镇痛的异氟烷麻醉组。各组术后运动活动无差异。在IL组中，通过大鼠面部表情量表评估的术后疼痛水平在术后8小时内显著增加，酮洛芬和吗啡均能同样抑制这种增加。从术后第3天开始连续12天使用放射状臂迷宫测试评估认知功能。结果显示，IL组的记忆错误数量显著高于C组。然而，酮洛芬和吗啡均可将术后记忆错误的增加程度减轻至相似水平。相反，酮洛芬对未经历疼痛的非手术大鼠的认知功能没有影响。我们的研究结果表明，酮洛芬术后镇痛可通过其止痛作用预防手术相关记忆缺陷的发生。
