Kawaguchi S
Department of Microbiology and Immunology, Shimane Medical University, Japan.
Immunology. 1989 Mar;66(3):335-8.
The reactivity of mouse antibodies against bromelain-treated mouse erythrocytes (BrMRBC) with mouse platelets before and after thrombin treatment was assessed by flow cytometry. Anti-BrMRBC antibodies could bind to thrombin-treated platelets, although normal platelets were also weakly reactive with the antibodies. The binding of anti-BrMRBC antibodies to platelets was confirmed by complement-dependent lysis. It is suggested that thrombin-activated platelets may be a real target for anti-BrMRBC antibodies.
通过流式细胞术评估小鼠抗菠萝蛋白酶处理的小鼠红细胞（BrMRBC）抗体与凝血酶处理前后小鼠血小板的反应性。抗BrMRBC抗体可与凝血酶处理的血小板结合，尽管正常血小板与该抗体也有微弱反应。抗BrMRBC抗体与血小板的结合通过补体依赖性溶解得到证实。提示凝血酶激活的血小板可能是抗BrMRBC抗体的真正靶标。
