Marchisio Paola, Nazzari Erica, Torretta Sara, Esposito Susanna, Principi Nicola
Department of Pathophysiology and Transplantation, Pediatric Highly Intensive Care Unit, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Expert Rev Anti Infect Ther. 2014 May;12(5):611-20. doi: 10.1586/14787210.2014.899902. Epub 2014 Mar 28.
Acute otitis media (AOM) is one of the most common pediatric diseases; almost all children experience at least one episode, and a third have two or more episodes in the first three years of life. The disease burden of AOM has important medical, social and economic effects. AOM requires considerable financial assistance due to needing at least one doctor visit and a prescription for antipyretics and/or antibiotics. AOM is also associated with high indirect costs, which are mostly related to lost days of work for one parent. Moreover, due to its acute symptoms and frequent recurrences, AOM considerably impacts both the child and family's quality of life. AOM prevention, particularly recurrent AOM (rAOM), is a primary goal of pediatric practice. In this paper, we review current evidence regarding the efficacy of medical treatments and vaccines for preventing rAOM and suggest the best approaches for AOM-prone children.
急性中耳炎(AOM)是最常见的儿科疾病之一;几乎所有儿童都至少经历过一次发作,三分之一的儿童在生命的头三年中有两次或更多次发作。AOM的疾病负担具有重要的医学、社会和经济影响。由于至少需要看一次医生并开具退烧药和/或抗生素的处方,AOM需要大量的经济援助。AOM还与高昂的间接成本相关,这主要与父母一方的误工天数有关。此外,由于其急性症状和频繁复发,AOM对儿童和家庭的生活质量有很大影响。预防AOM,尤其是复发性AOM(rAOM),是儿科实践的主要目标。在本文中,我们回顾了有关预防rAOM的药物治疗和疫苗疗效的现有证据,并为易患AOM的儿童提出了最佳方法。