Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.
Br J Ophthalmol. 2014 Aug;98(8):1056-60. doi: 10.1136/bjophthalmol-2013-304493. Epub 2014 Mar 28.
Provide insight in natural history, screening and treatment policy of retinopathy of prematurity (ROP) in The Netherlands.
A multicentre, prospective, population-based study (NEDROP) included all preterm infants born in 2009 in The Netherlands fulfilling the inclusion criteria for ROP screening. Anonymised data from ophthalmologists, neonatologists and paediatricians were merged on identification number.
Of 2033 reported infants, 1688 (83%) were screened for ROP. ROP stage was reported in 100%, zone in 94.4% and plus disease in 83%. ROP developed in 324 (19.2%), mild ROP (stage 1-2) in 294 (17.4%), severe ROP (stage 3 or more) in 30 (1.8%) and 17 (1%) were treated. The initial screening examination was not performed within the required 42 days in 641 (38%). Date for follow-up was recorded 1973 times and accomplished within 3 days from the planned date in 1957 (99.2%). The chance of not being screened increased from 12.9% without transfer to another hospital to 23.5, 18.5 and 25% after 1, 2, or 3 transfers, respectively.
The incidence of severe ROP and infants treated was low. NEDROP emphasises that timing of initial examination and transfer to another hospital are issues of concern within the screening process.
提供荷兰早产儿视网膜病变（ROP）自然史、筛查和治疗政策的见解。
一项多中心、前瞻性、基于人群的研究（NEDROP）纳入了荷兰 2009 年出生的所有符合 ROP 筛查条件的早产儿。眼科医生、新生儿科医生和儿科医生的匿名数据按识别号合并。
在报告的 2033 名婴儿中，有 1688 名（83%）接受了 ROP 筛查。100%报告了 ROP 分期，94.4%报告了 ROP 区，83%报告了合并疾病。324 名（19.2%）发生 ROP，轻度 ROP（1-2 期）294 名（17.4%），重度 ROP（3 期或以上）30 名（1.8%），17 名（1%）接受治疗。641 名（38%）未在规定的 42 天内进行初始筛查检查。记录了 1973 次随访日期，其中 1957 次（99.2%）在计划日期的 3 天内完成。没有转院的婴儿未被筛查的几率为 12.9%，而转院 1、2、3 次后，未被筛查的几率分别增加到 23.5%、18.5%和 25%。
严重 ROP 和接受治疗的婴儿比例较低。NEDROP 强调，初始检查和转院时间是筛查过程中的关注问题。
