The Second Affiliated Hospital of Guangzhou Medical University, Changgang Dong Lu, No. 250, Guangzhou, 510260, China,
J Endocrinol Invest. 2014 Apr;37(4):339-44. doi: 10.1007/s40618-013-0018-9. Epub 2014 Jan 9.
To investigate whether the metabolic syndrome (MetS) is a risk factor for lower urinary tract symptoms (LUTS), as defined by the International Prostate Symptom Score in a Chinese male population with benign prostate hyperplasia (BPH).
We retrospectively analyzed the clinical data obtained from 1,052 Chinese men with BPH. Serum levels of prostate specific antigen, fasting blood glucose (FBG), high-density lipoprotein cholesterol, total cholesterol and triglyceride were determined and recorded. Multiple logistic regression statistical analysis was used to investigate the degree of the association between LUTS and MetS.
Of the 1,052 enrolled patients, 648 (61.60 %) had moderate LUTS and 404 (38.40 %) had severe LUTS. A multiple logistic regression analysis showed that age (OR 2.02, 95 % CI 1.04-4.63), FBG (OR 3.65, 95 % CI 1.68-7.98) and presence of MetS (OR 3.64, 95 % CI 1.24-6.14) were significant predictors of severe LUTS.
The results of our study suggest that MetS is associated with an increase risk of total volume and annual growth rate of prostate.
研究代谢综合征（MetS）是否是良性前列腺增生（BPH）中国男性人群中根据国际前列腺症状评分（IPSS）定义的下尿路症状（LUTS）的危险因素。
我们回顾性分析了 1052 名中国 BPH 男性患者的临床资料。测定并记录了前列腺特异性抗原、空腹血糖（FBG）、高密度脂蛋白胆固醇、总胆固醇和甘油三酯的血清水平。采用多因素 logistic 回归统计分析方法探讨 LUTS 与 MetS 之间的关联程度。
在纳入的 1052 名患者中，648 名（61.60%）有中度 LUTS，404 名（38.40%）有重度 LUTS。多因素 logistic 回归分析显示，年龄（OR 2.02，95%CI 1.04-4.63）、FBG（OR 3.65，95%CI 1.68-7.98）和 MetS 的存在（OR 3.64，95%CI 1.24-6.14）是重度 LUTS 的显著预测因素。
本研究结果表明，MetS 与前列腺总体积和年增长率增加的风险相关。
