Wong Samuel Y, Woo Jean, Hong Athena, Leung Jason C S, Kwok Timothy, Leung Ping C
Department of Community and Family Medicine, Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Urology. 2006 Nov;68(5):1009-14. doi: 10.1016/j.urology.2006.05.039. Epub 2006 Nov 7.
To study, in a large prospective cohort study of 2000 Chinese men 65 to 92 years of age in Hong Kong, the role of lifestyle and medical risk factors for moderate to severe lower urinary tract symptoms (LUTS). Previous epidemiologic studies evaluating the risk factors for LUTS were mainly conducted in non-Chinese populations.
After excluding men with prostate or bladder cancer or surgery and those who took alpha-blockers and antiandrogens, 1739 subjects provided responses to a structured interviewer-administered questionnaire and physical examination.
A clustered case-control analysis was performed, comparing subjects with moderate to severe LUTS with those with mild or no LUTS. A total of 38.2% of subjects had moderate to severe LUTS. On multiple logistic regression analysis, a history of heart disease was independently associated with an increased risk of moderate to severe LUTS (odds ratio 1.50, 95% confidence interval 1.13 to 1.98). Physical activity was independently associated with reduced risk of moderate to severe LUTS (odds ratio 0.66, 95% confidence interval 0.48 to 0.90). A mild increase in the body mass index (23 to 24.9 kg/m2) was associated with a reduced risk of LUTS (odds ratio 0.72, 95% confidence interval 0.56 to 0.93).
These results have shown that LUTS are a significant health problem in Chinese men and that, similar to results from previous studies, LUTS are associated with medical and lifestyle factors in the Chinese.
在一项针对香港2000名65至92岁中国男性的大型前瞻性队列研究中，探讨生活方式和医学风险因素在中重度下尿路症状（LUTS）中的作用。以往评估LUTS风险因素的流行病学研究主要在非中国人群中进行。
排除患有前列腺癌或膀胱癌、接受过手术以及正在服用α受体阻滞剂和抗雄激素药物的男性后，1739名受试者接受了结构化的访谈式问卷调查和体格检查。
进行了聚类病例对照分析，将中重度LUTS患者与轻度或无LUTS患者进行比较。共有38.2%的受试者患有中重度LUTS。多因素logistic回归分析显示，心脏病史与中重度LUTS风险增加独立相关（优势比1.50，95%置信区间1.13至1.98）。身体活动与中重度LUTS风险降低独立相关（优势比0.66，95%置信区间0.48至0.90）。体重指数轻度升高（23至24.9kg/m²）与LUTS风险降低相关（优势比0.72，95%置信区间0.56至0.93）。
这些结果表明，LUTS在中国男性中是一个重要的健康问题，并且与以往研究结果相似，LUTS与中国人的医学和生活方式因素相关。
