Beijing National Laboratory for Molecular Science (BNLMS), Key Laboratory of Green Printing, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing (P. R. China) http://ylsong.iccas.ac.cn; University of Chinese Academy of Sciences, Beijing (P. R. China).
Angew Chem Int Ed Engl. 2014 Jun 2;53(23):5791-5. doi: 10.1002/anie.201400686. Epub 2014 Mar 28.
Ultratrace detection attracts great interest because it is still a challenge to the early diagnosis and drug testing. Enriching the targets from highly diluted solutions to the sensitive area is a promising method. Inspired by the fog-collecting structure on Stenocara beetle's back, a photonic-crystal (PC) microchip with hydrophilic-hydrophobic micropattern was fabricated by inkjet printing. This device was used to realize high-sensitive ultratrace detection of fluorescence analytes and fluorophore-based assays. Coupled with the fluorescence enhancement effect of a PC, detection down to 10(-16) mol L(-1) was achieved. This design can be combined with biophotonic devices for the detection of drugs, diseases, and pollutions of the ecosystem.
超痕量检测引起了极大的兴趣，因为它仍然是早期诊断和药物检测的挑战。将目标从高度稀释的溶液富集到敏感区域是一种很有前途的方法。受 Stenocara 甲虫背部集雾结构的启发，通过喷墨打印制造了具有亲水性-疏水性微图案的光子晶体（PC）微芯片。该装置用于实现荧光分析物和基于荧光团的分析物的高灵敏超痕量检测。与 PC 的荧光增强效应相结合，实现了低至 10(-16) mol L(-1)的检测。这种设计可以与生物光子学器件结合，用于检测药物、疾病和生态系统的污染。
