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喷墨打印直写胶体光子晶体微流控芯片用于无标记蛋白质检测。

Direct-writing colloidal photonic crystal microfluidic chips by inkjet printing for label-free protein detection.

机构信息

Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.

出版信息

Lab Chip. 2012 Sep 7;12(17):3089-95. doi: 10.1039/c2lc40311k. Epub 2012 Jul 5.

Abstract

Integrating photonic crystals (PC) into microfluidic systems has attracted immense interest for its novel functions. However, it is still a great challenge to fabricate PC microfluidic chips rapidly with complex functions. In this work, a direct-writing colloidal PC microchannel was firstly achieved by inkjet printing and was used for the surface-tension-confined microfluidic immune assay. PC channels with different structure colors have been successfully integrated on one chip. The fabricated chip has the advantages of rapid fabrication, quick fluidic transport and can monitor the fluidic fluxion using the naked eye. Utilizing this PC microfluidic chip, a colorimetric label-free immune assay was realized without nonspecific adsorption interference of the target.

摘要

将光子晶体(PC)集成到微流控系统中因其新颖的功能而引起了极大的关注。然而,用复杂的功能快速制造 PC 微流控芯片仍然是一个巨大的挑战。在这项工作中,首次通过喷墨打印实现了直接书写胶体光子晶体微通道,并将其用于表面张力限制的微流控免疫分析。已经成功地将具有不同结构颜色的 PC 通道集成在一个芯片上。所制造的芯片具有快速制造、快速流体传输的优点,并且可以用肉眼监测流体的流动。利用这种 PC 微流控芯片,实现了无需目标非特异性吸附干扰的比色标记免疫分析。

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