Shurbaji M S, Gupta P K, Frost J K
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21205.
Diagn Cytopathol. 1988;4(2):91-4. doi: 10.1002/dc.2840040202.
A recent report emphasized the usefulness of the grooved nucleus as a diagnostic criterion of papillary thyroid carcinoma (PTC) in histopathologic material. The present study was undertaken to evaluate whether grooved nuclei can serve as an additional diagnostic criterion for PTC in cytologic material obtained by fine-needle aspiration (FNA). Slides from 124 consecutive thyroid FNAs were reviewed. Specimens included 11 PTCs, one follicular carcinoma, six follicular adenomas, eight follicular neoplasms not otherwise specified, 10 cases of chronic thyroiditis, and 88 colloid nodules/adenomatous goiters. Among the PTC cases, grooved nuclei were found in all 11 (100%), intranuclear inclusions in nine (82%), papillary fragments in seven (64%), and psammoma bodies in two (18%). Nuclear grooves were also observed in two of the 113 non-PTC cases (1.8%), both of which were colloid nodules, one with extensive Hurthle-cell change. The grooved nuclei were best identified on Papanicolaou-stained material. They were inconspicuous and difficult to identify in air-dried Diff-Quik-stained material. It appears that the recognition of grooved nuclei among tumor cells is a valuable diagnostic feature of PTC in cytologic material stained with polychromatic Papanicolaou stain.
最近的一份报告强调了沟状核作为甲状腺乳头状癌（PTC）组织病理学诊断标准的有用性。本研究旨在评估在细针穿刺（FNA）获取的细胞学材料中，沟状核是否可作为PTC的额外诊断标准。回顾了124例连续甲状腺FNA的玻片。标本包括11例PTC、1例滤泡癌、6例滤泡性腺瘤、8例未另行指定的滤泡性肿瘤、10例慢性甲状腺炎以及88例胶样结节/腺瘤性甲状腺肿。在PTC病例中，11例（100%）均发现有沟状核，9例（82%）有核内包涵体，7例（64%）有乳头碎片，2例（18%）有砂粒体。在113例非PTC病例中的2例（1.8%）也观察到核沟，这2例均为胶样结节，其中1例有广泛的许特耳细胞改变。沟状核在巴氏染色材料上最易识别。在空气干燥的Diff-Quik染色材料中不明显且难以识别。在经多色巴氏染色的细胞学材料中，肿瘤细胞中沟状核的识别似乎是PTC的一个有价值的诊断特征。
