Pan Zhenghong, Ning Desheng, Wu Xingde, Huang Sisi, Li Dianpeng, Lv Shihong
Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, PR China.
Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, PR China.
Bioorg Med Chem Lett. 2015 Mar 15;25(6):1329-32. doi: 10.1016/j.bmcl.2015.01.033. Epub 2015 Feb 3.
Three new nor-clerodane diterpenoids, crotoeurins A-C (1-3), together with four known ones were isolated from the twigs and leaves of Croton euryphyllus. Among them, crotoeurin A (1) is a new nor-clerodane diterpenoid dimer with a unique cyclobutane ring via a [2+2] cycloaddition. Their structures were elucidated by spectroscopic analyses and the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis. Compounds 1-3 exhibited neurite outgrowth-promoting activity on NGF-mediated PC12 cells at concentration of 10μM.
从宽叶巴豆的嫩枝和叶子中分离出了三种新的降香紫苏烷二萜类化合物，巴豆优素A-C（1-3），以及四种已知化合物。其中，巴豆优素A（1）是一种新的降香紫苏烷二萜类二聚体，通过[2+2]环加成反应形成了独特的环丁烷环。通过光谱分析确定了它们的结构，并通过单晶X射线衍射分析证实了1的立体化学结构。化合物1-3在浓度为10μM时对NGF介导的PC12细胞表现出促进神经突生长的活性。
