Mehr Sam, Frith Katie, Campbell Dianne E
aDepartment of Allergy and Immunology, The Children's Hospital at Westmead, Westmead bDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick cSydney University, Sydney, New South Wales, Australia.
Curr Opin Allergy Clin Immunol. 2014 Jun;14(3):208-16. doi: 10.1097/ACI.0000000000000056.
To summarize the epidemiology of food protein-induced enterocolitis syndrome (FPIES).
FPIES is regarded as a rare non-IgE-mediated gastrointestinal allergic disorder. Older nonpopulation-based studies reported an average of 1-15 cases presenting to allergy clinics a year, but recent studies have reported figures as high as 90 cases a year. The yearly incidence of FPIES in one Australian study was one in 10,000 infants less than 2 years of age. Chronic FPIES typically presents in neonates, whereas acute FPIES is primarily a disorder of young infants. FPIES has a slight male predominance; eczema and a family history of atopy are commonly present at diagnosis; almost one in 10 infants have coexistent IgE food allergies and siblings are rarely affected. There is regional variation in common triggering foods, rates of combined cow milk and soy FPIES and multiple food group FPIES. Understanding of the epidemiology of FPIES is limited by the lack of a universally accepted definition and the publication of few prospective population-based case series.
FPIES is not as rare as once thought, but how common it is, what factors predispose to its development, and why there is regional variation needs to be addressed by future well designed population-based studies?
总结食物蛋白诱导的小肠结肠炎综合征（FPIES）的流行病学。
FPIES被认为是一种罕见的非IgE介导的胃肠道过敏性疾病。早期非基于人群的研究报告称，每年平均有1 - 15例患者前往过敏诊所就诊，但最近的研究报告的数字高达每年90例。一项澳大利亚研究显示，2岁以下婴儿中FPIES的年发病率为万分之一。慢性FPIES通常在新生儿中出现，而急性FPIES主要是幼儿的疾病。FPIES男性略占优势；诊断时通常伴有湿疹和特应性家族史；近十分之一的婴儿同时存在IgE介导的食物过敏，且兄弟姐妹很少受影响。常见触发食物、牛奶和大豆联合FPIES以及多种食物组FPIES的发生率存在地区差异。由于缺乏普遍接受的定义以及很少有基于人群的前瞻性病例系列发表，对FPIES流行病学的了解有限。
FPIES并不像曾经认为的那么罕见，但它究竟有多常见、哪些因素易导致其发生以及为何存在地区差异，需要未来设计良好的基于人群的研究来解决。
