O'Gorman Aoife, Gibbons Helena, Brennan Lorraine
UCD Conway Institute, Belfield, Dublin, Ireland ; UCD Institute of Food and Health, Belfield, Dublin, Ireland.
Comput Struct Biotechnol J. 2013 Feb 7;4:e201301004. doi: 10.5936/csbj.201301004. eCollection 2013.
Traditional methods for assessing dietary exposure can be unreliable, with under reporting one of the main problems. In an attempt to overcome such problems there is increasing interest in identifying biomarkers of dietary intake to provide a more accurate measurement. Metabolomics is an analytical technique that aims to identify and quantify small metabolites. Recently, there has been an increased interest in the application of metabolomics coupled with statistical analysis for the identification of dietary biomarkers, with a number of putative biomarkers identified. This minireview focuses on metabolomics based approaches and highlights some of the key successes.
传统的膳食暴露评估方法可能不可靠，漏报是主要问题之一。为了克服这些问题，人们越来越关注识别膳食摄入量的生物标志物，以提供更准确的测量。代谢组学是一种旨在识别和量化小分子代谢物的分析技术。最近，人们对将代谢组学与统计分析相结合以识别膳食生物标志物的应用兴趣日益浓厚，已经确定了一些假定的生物标志物。本综述聚焦于基于代谢组学的方法，并突出了一些关键的成功案例。
