Nakagawa Koji, Ojiro Yuko, Jyuen Hiroyasu, Nishi Yayoi, Sugiyama Rie, Kuribayashi Yasushi, Sugiyama Rikikazu
Division of Reproductive Medicine, Sugiyama Clinic, Tokyo, Japan.
J Obstet Gynaecol Res. 2014 May;40(5):1331-7. doi: 10.1111/jog.12328. Epub 2014 Apr 2.
To determine the efficacy of prostaglandin administration during the proliferative phase in order to improve pregnancy rates following frozen embryo transfer during a hormone replacement cycle (HRC).
From September 2010 through March 2012, patients (n = 135) were recruited who had undergone oocyte retrieval during a stimulation cycle with clomiphene and had deferred fresh embryo transfer (ET) due to a thin uterine endometrium. All patients were less than 40 years of age and underwent thawed ET following all embryo cryopreservation, and were randomly divided into two groups for thawed ET using a conventional hormone replacement cycle with or without prostaglandin derivatives (prostaglandin or conventional group). Prostaglandin derivatives were administrated during the proliferative phase. Pregnancy and implantation rates following frozen ET were compared between the two groups.
Although the endometrial thickness on the day of ET was similar for the prostaglandin and conventional groups, the pregnancy and implantation rates for the prostaglandin group were 40.0% and 22.0%, respectively, which was significantly higher than the rates for the conventional group (P < 0.01).
Among patients who avoided fresh ET due to a thin endometrium, the pregnancy rate following a thawed cycle was low. However, it was improved when prostaglandin derivatives were used during the proliferative phase.
确定在增殖期给予前列腺素以提高激素替代周期（HRC）中冻融胚胎移植后的妊娠率的疗效。
从2010年9月至2012年3月，招募了135例患者，这些患者在克罗米芬刺激周期中进行了取卵，并且由于子宫内膜薄而推迟了新鲜胚胎移植（ET）。所有患者年龄均小于40岁，在所有胚胎冷冻保存后均接受了冻融胚胎移植，并随机分为两组，分别采用含或不含前列腺素衍生物的传统激素替代周期进行冻融胚胎移植（前列腺素组或传统组）。在增殖期给予前列腺素衍生物。比较两组冻融胚胎移植后的妊娠率和着床率。
虽然前列腺素组和传统组在胚胎移植当天的子宫内膜厚度相似，但前列腺素组的妊娠率和着床率分别为40.0%和22.0%，显著高于传统组（P<0.01）。
在因子宫内膜薄而避免新鲜胚胎移植的患者中，冻融周期后的妊娠率较低。然而，在增殖期使用前列腺素衍生物时妊娠率有所提高。
