Nakagawa Koji, Kaneyama Masayo, Nishi Yayoi, Sugiyama Rie, Motoyama Hiroshi, Sugiyama Rikikazu
Division of Reproductive Medicine Sugiyama Clinic 1-53-1, Ohara 156-0041 Tokyo Setagaya Japan.
Center for Reproductive Medicine and Endoscopy Sugiyama Clinic Tokyo Marunouchi Japan.
Reprod Med Biol. 2014 Oct 17;14(2):73-78. doi: 10.1007/s12522-014-0195-z. eCollection 2015 Apr.
To investigate whether clomiphene citrate (CC) affects uterine receptivity or not, we evaluated pregnancy rates (PR) during the hormone replacement cycle (HRC) according to the period between the last day of CC administration and the day of embryo transfer (ET).
From March 2008 through March 2010, a total of 378 treatment cycles among 378 patients who received CC and had to avoid fresh ET due to a thin uterine endometrium were recruited. All patients underwent thawed ET using HRC. PRs were evaluated according to the period between the last CC treatment and the day of ET.
PR for the groups in which the period between the last CC treatment and the day of ET increased to more than 91 days were significantly higher than that for group in which the period was less than 90 days ( < 0.05).
A lower PR was shown by the patients who underwent thawed ET in the HRC within 90 days after their last CC treatment, which shows that CC affects the receptivity of the uterine endometrium.
为了研究枸橼酸氯米芬（CC）是否会影响子宫容受性，我们根据CC给药最后一天与胚胎移植（ET）日之间的时间间隔，评估了激素替代周期（HRC）期间的妊娠率（PR）。
从2008年3月至2010年3月，共招募了378例接受CC治疗且因子宫内膜薄而不得不避免新鲜胚胎移植的患者的378个治疗周期。所有患者均采用HRC进行解冻胚胎移植。根据最后一次CC治疗与ET日之间的时间间隔评估PR。
最后一次CC治疗与ET日之间的时间间隔增加到91天以上的组的PR显著高于时间间隔小于90天的组（<0.05）。
在最后一次CC治疗后90天内接受HRC解冻胚胎移植的患者显示出较低的PR，这表明CC会影响子宫内膜的容受性。
