Pedersen C, Horn T, Junge J, Haahr S, Nielsen J O
Department of Infectious Diseases, University of Copenhagen, Hvidovre Hospital, Denmark.
APMIS. 1989 Mar;97(3):249-52. doi: 10.1111/j.1699-0463.1989.tb00784.x.
Skin biopsies obtained from apparently normal skin from 15 HIV infected patients and 6 anti-HIV negative patients were examined by electron microscopy. Tubuloreticular inclusions (TRI) were detected within the cytoplasm of capillary endothelial cells in 5/5 AIDS patients and in 2/5 patients with AIDS related conditions. Biopsies from 5 asymptomatic HIV positive patients and the 6 control subjects were without ultrastructural alterations. The occurrence of TRI was related to low numbers of CD 4+ lymphocytes. 5/7 patients with TRI had elevated serum interferon activity, and in all of the patients without TRI, interferon activity was below detection level. The occurrence of TRI was not dependent on the presence of free p24 antigen in serum. It is concluded that the occurrence of TRI in entothelial cells of skin capillaries is associated with late stages of HIV infection and this may indicate a generalization of this change.
对15名HIV感染患者和6名抗HIV阴性患者看似正常的皮肤进行活检，并通过电子显微镜检查。在5例艾滋病患者中的5例以及5例艾滋病相关疾病患者中的2例的毛细血管内皮细胞胞质内检测到管状网状包涵体（TRI）。5例无症状HIV阳性患者和6名对照受试者的活检未发现超微结构改变。TRI的出现与CD4 +淋巴细胞数量少有关。7例有TRI的患者中有5例血清干扰素活性升高，而所有没有TRI的患者中，干扰素活性低于检测水平。TRI的出现不依赖于血清中游离p24抗原的存在。得出的结论是，皮肤毛细血管内皮细胞中TRI的出现与HIV感染的晚期有关，这可能表明这种变化具有普遍性。
