School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA, USA.
Phys Med Biol. 2010 Feb 21;55(4):947-62. doi: 10.1088/0031-9155/55/4/003. Epub 2010 Jan 20.
Optical imaging has been widely applied in preclinical and clinical applications. Fifteen years ago, an efficient Monte Carlo program 'MCML' was developed for use with multi-layered turbid media and has gained popularity in the field of biophotonics. Currently, there is an increasingly pressing need for simulating tools more powerful than MCML in order to study light propagation phenomena in complex inhomogeneous objects, such as the mouse. Here we report a tetrahedron-based inhomogeneous Monte Carlo optical simulator (TIM-OS) to address this issue. By modeling an object as a tetrahedron-based inhomogeneous finite-element mesh, TIM-OS can determine the photon-triangle interaction recursively and rapidly. In numerical simulation, we have demonstrated the correctness and efficiency of TIM-OS.
光学成像是广泛应用于临床前和临床应用。十五年前，开发了一个高效的用于多层混浊介质的蒙特卡罗程序“MCML”，并在生物光子学领域广受欢迎。目前，人们越来越需要比 MCML 更强大的模拟工具来研究复杂非均匀物体中的光传播现象，例如老鼠。在这里，我们报告了一种基于四面体的非均匀蒙特卡罗光学模拟器（TIM-OS）来解决这个问题。通过将物体建模为基于四面体的非均匀有限元网格，TIM-OS 可以递归且快速地确定光子-三角形相互作用。在数值模拟中，我们验证了 TIM-OS 的正确性和效率。
