Effect of selected Samana and Vicitra Pratyayarabdha Dravya w.s.r. to Vipaka.

Concept of Arabdhata and Pratyayarabdhata is a unique concept of Ayurveda, which is related to the conjugation and configuration of Mahabhutas (penta elements). Every substance undergoes some changes during digestion and metabolism in terms of changes in its Panchabhautika composition. If substance retains its Panchabhautika composition throughout the digestion and metabolism, it is known as Samana Pratyayarabdhata and if Panchabhautika composition of substance becomes totally different after digestion and metabolism, it is known as Vicitra Pratyayarabdhata. The change in Panchabhautika composition of substance can be seen at the level of Vipaka (post-digestive effect) or Virya (potency), which are not found according to Rasa (taste) and hence the Karma (action) of substance becomes different from its Rasa. Therefore, four drugs were selected, two having Samana Pratyayarabdhata (Nimba and Vasa) and two having Vicitra Pratyayarabdhata (Bhumyamalaki and Shankhapushpi). Clinical study was carried out on 24 healthy volunteers having Madhyama Koshta, divided into four groups, one group for each drug. The effects of drugs were assessed according to their Vipaka on Koshta (Bowel habit) especially on stool and habit of defecation (Srishtavinmutrata or Baddhavinmutrata). All the drugs showed effect according to their Vipaka in few parameters, but most of the results were statistically insignificant which suggested that substances perform their action according to their Pratyayarabdhata.