Martí Meritxell, Martínez Vanessa, Carreras Núria, Alonso Cristina, Lis Manuel José, Parra José Luis, Coderch Luisa
Department of Chemical and Surfactants Technology, Institute of Advanced Chemistry of Catalonia, (IQAC-CSIC) , Barcelona , Spain and.
J Microencapsul. 2014;31(6):535-41. doi: 10.3109/02652048.2014.885605. Epub 2014 Apr 3.
Abstract The aim of this study was to demonstrate the skin penetration of an antioxidant, gallic acid (GA), encapsulated in poly-ε-caprolactone (PCL) microspheres and applied onto textile fabrics, by a specific in vitro percutaneous absorption methodology. Two techniques (particle size distribution and FTIR) were used to characterise the microspheres obtained. The amount of GA-loaded microspheres present in the biofunctional textiles was established before their use as a textile drug delivery system. More absorption and desorption of microspheres with GA for the polyamide fabric were found in comparison with cotton fabric. The percutaneous absorption results indicated that the skin penetration of GA released from PCL-microspheres that were applied directly to the skin was higher than when GA was embedded within biofunctional textiles, in conclusion, an interesting reservoir effect may be promoted when biofunctional textiles were used.
摘要 本研究的目的是通过一种特定的体外经皮吸收方法,证明封装在聚ε-己内酯(PCL)微球中并应用于织物上的抗氧化剂没食子酸(GA)的皮肤渗透性。使用两种技术(粒度分布和傅里叶变换红外光谱)对所得微球进行表征。在将载有GA的微球用作织物药物递送系统之前,确定了其在生物功能纺织品中的含量。与棉织物相比,发现聚酰胺织物对含GA微球的吸收和解吸更多。经皮吸收结果表明,直接应用于皮肤的PCL微球释放的GA的皮肤渗透性高于GA嵌入生物功能纺织品中的情况。总之,使用生物功能纺织品时可能会促进有趣的储库效应。