由炔酮高效合成呋喃-3(2)-亚胺骨架。
An efficient synthesis of furan-3(2)-imine scaffold from alkynones.
作者信息
Rasras Anas J, Shehadi Ihsan A, Younes Eyad A, Jaradat Da'san M M, AlQawasmeh Raed A
机构信息
Faculty of Science, Department of Chemistry, Al-Balqa Applied University, PO Box 19117, Al-Salt, Jordan.
College of Science, Department of Chemistry, University of Sharjah, Pure and Applied Chemistry Research Group, PO Box 27272, Sharjah, United Arab Emirates.
出版信息
R Soc Open Sci. 2021 Nov 24;8(11):211145. doi: 10.1098/rsos.211145. eCollection 2021 Nov.
A novel efficient method to generate spiro furan-3(2)-imine derivatives is established by the reaction between the ,-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS).
通过α,β-不饱和酮与苯胺衍生物之间的反应，建立了一种新颖高效的生成螺环呋喃-3(2)-亚胺衍生物的方法。该反应包括苯胺的1,4-加成，随后由叔醇介导进行分子内环化以生成呋喃-3(2)-亚胺。所有合成的化合物均通过核磁共振和高分辨率质谱（HRMS）进行表征。
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