Salikhova N N, Akhmedzhanov R I, Mukhamadieva Sh G, Sakhibov A D
Lab Delo. 1989(3):48-52.
Gel chromatography and high performance liquid chromatography have been applied to analysis of the blood serum peptides in renal patients. The levels of the peptides with a molecular mass of 300-5000 D have been found to correlate with the severity of the kidney involvement. A rapid method for measuring the concentrations of these peptides has been developed, based on the precipitation of the blood serum high-molecular peptides followed by measurement of the concentration of the peptides remaining in the supernatant with the use of a specific reagent. The suggested method has been used to define the severity of the kidney involvement and to monitor the efficacy of hemodialysis and hemoperfusion.
凝胶色谱法和高效液相色谱法已应用于肾病患者血清肽的分析。已发现分子量为300 - 5000 D的肽水平与肾脏受累的严重程度相关。基于血清高分子肽的沉淀，随后使用特定试剂测量上清液中剩余肽的浓度，开发了一种快速测量这些肽浓度的方法。所建议的方法已用于确定肾脏受累的严重程度，并监测血液透析和血液灌流的疗效。
