Department of Infectious Diseases, Tokyo Women's Medical University Hospital, Shinjuku-ku, Tokyo, Japan; Department of Haematology, Tokyo Women's Medical University Hospital, Shinjuku-ku, Tokyo, Japan.
Department of Infectious Diseases, Tokyo Women's Medical University Hospital, Shinjuku-ku, Tokyo, Japan.
J Hosp Infect. 2014 May;87(1):54-8. doi: 10.1016/j.jhin.2014.02.006. Epub 2014 Mar 12.
A retrospective analysis was undertaken from 2000 to 2010 to show the risk factors associated with death within 30 days in patients with C. parapsilosis candidaemia (CPC). Fifty-one cases of nosocomial CPC were included in the analysis. All isolates from blood cultures were susceptible to micafungin and fluconazole. The overall mortality rate was 23.5%, and the most severe complications were endocarditis (5.9%) and endophthalmitis (5.9%). On multi-variate analysis, APACHE II score >25 (odds ratio 43.9) and retained cardiovascular prosthetic materials (RCPM) (prosthetic valve or graft) (odds ratio 14.6) were found to be risk factors associated with death. Prompt surgical removal should be considered in CPC patients with RCPM.
回顾性分析 2000 年至 2010 年期间，以明确与近平滑念珠菌菌血症（CPC）患者 30 天内死亡相关的危险因素。分析纳入了 51 例医院获得性 CPC 病例。所有血液培养分离株均对米卡芬净和氟康唑敏感。总体死亡率为 23.5%，最严重的并发症为心内膜炎（5.9%）和眼内炎（5.9%）。多变量分析发现，APACHE II 评分>25（比值比 43.9）和存在心血管假体材料（RCPM）（人工瓣膜或移植物）（比值比 14.6）是与死亡相关的危险因素。对于存在 RCPM 的 CPC 患者，应考虑及时进行外科手术切除。
