1] Institute of Molecular Biology, Mainz, Germany. [2].
Nat Struct Mol Biol. 2014 Apr;21(4):317-24. doi: 10.1038/nsmb.2805.
Many aspects of nucleic acid metabolism, such as DNA replication, repair and transcription, are regulated by the post-translational modifiers ubiquitin and SUMO. Not surprisingly, DNA itself plays an integral part in determining the modification of most chromatin-associated targets. Conversely, ubiquitination or SUMOylation of a protein can impinge on its DNA-binding properties. This review describes mechanistic principles governing the mutual interactions between DNA and ubiquitin or SUMO.
许多核酸代谢过程，如 DNA 复制、修复和转录，都受到泛素和 SUMO 等翻译后修饰物的调节。毫不奇怪，DNA 本身在决定大多数与染色质相关的靶标的修饰中起着不可或缺的作用。相反，蛋白质的泛素化或 SUMO 化会影响其 DNA 结合特性。本文综述了 DNA 与泛素或 SUMO 相互作用的机制原理。
