重组酶聚合酶扩增（RPA）抑制了微同源性介导的末端连接（MMEJ）。 - Suppr

RPA puts the brakes on MMEJ.

作者信息

McVey Mitch

机构信息

Department of Biology, Tufts University, Medford, Massachusetts, USA.

出版信息

Nat Struct Mol Biol. 2014 Apr;21(4):348-9. doi: 10.1038/nsmb.2802.

DOI:10.1038/nsmb.2802

PMID:24699084

Abstract

摘要

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本文引用的文献

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Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7720-5. doi: 10.1073/pnas.1213431110. Epub 2013 Apr 22.

Alternative end-joining mechanisms: a historical perspective.

Front Genet. 2013 Apr 2;4:48. doi: 10.3389/fgene.2013.00048. eCollection 2013.

The structure and function of replication protein A in DNA replication.

Subcell Biochem. 2012;62:171-96. doi: 10.1007/978-94-007-4572-8_10.

Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining.

Am J Cancer Res. 2012;2(3):249-68. Epub 2012 Apr 21.

Double-strand break end resection and repair pathway choice.

Annu Rev Genet. 2011;45:247-71. doi: 10.1146/annurev-genet-110410-132435. Epub 2011 Sep 12.

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway.

Nat Struct Mol Biol. 2011 Jan;18(1):80-4. doi: 10.1038/nsmb.1940. Epub 2010 Dec 5.

Replication protein A: directing traffic at the intersection of replication and repair.

Front Biosci (Landmark Ed). 2010 Jun 1;15(3):883-900. doi: 10.2741/3652.

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies.

Nucleic Acids Res. 2010 Oct;38(18):6065-77. doi: 10.1093/nar/gkq387. Epub 2010 May 18.

Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells.

PLoS Genet. 2010 Feb 26;6(2):e1000855. doi: 10.1371/journal.pgen.1000855.

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RPA puts the brakes on MMEJ.

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