Gomez-Marcos Manuel A, Gonzalez-Sarmiento Rogelio, Recio-Rodríguez José I, Agudo-Conde Cristina, Gamella-Pozuelo Luis, Perretta-Tejedor Nuria, Martínez-Salgado Carlos, García-Ortiz Luis
Instituto de Investigación Biomédica de Salamanca (IBSAL). Primary Care Research Unit, La Alamedilla Health Center, Castilla and León Health Service-SACYL, Salamanca, Spain.
BMJ Open. 2014 Apr 3;4(4):e005112. doi: 10.1136/bmjopen-2014-005112.
Target organ damage (TOD) is associated with increased cardiovascular risk. The study objectives were to analyse the relationship of TOD to blood pressure, size of retinal arteries and veins, oxidative stress and different polymorphisms in the VAV-2 and VAV-3 genes in participants with hypertension.
A case-control study to analyse the relationship between clinical, biochemical and genetic parameters and presence of cardiac, vascular and renal TOD in 486 patients with hypertension. Participants with TOD will be considered as cases, and those without TOD will be enrolled as controls. This will be a collaborative study conducted by the groups of Primary Care, Cardiovascular and Metabolic and Degenerative Diseases of the Instituto de Investigación Biomédica of Salamanca (IBSAL). Assessment of cardiac, renal and vascular TOD. Measurement of peripheral and central blood pressure, size of eye fundus arteries and veins, and oxidative stress, and polymorphisms in the VAV-2 and VAV-3 genes.
The study will be conducted after approval is obtained from the Ethics Committee of Hospital Clínico Universitario of Salamanca. All study participants will sign an informed consent to agree to participate in the study, and another consent to agree on the genetic study, in compliance with the Declaration of Helsinki and the WHO standards for observational studies. The results of this study will allow for an understanding of the relationship of the different TODs with blood pressure, retinal artery and vein diameters, oxidative stress and polymorphisms in VAV-2 and VAV-3 genes.
Clinical Trials. gov Identifier: NCT02022618.
靶器官损害（TOD）与心血管风险增加相关。本研究的目的是分析高血压患者中TOD与血压、视网膜动静脉大小、氧化应激以及VAV - 2和VAV - 3基因不同多态性之间的关系。
一项病例对照研究，分析486例高血压患者的临床、生化和遗传参数与心脏、血管和肾脏TOD存在情况之间的关系。有TOD的参与者将被视为病例，无TOD的参与者将被纳入对照组。这将是由萨拉曼卡生物医学研究所（IBSAL）的初级保健、心血管与代谢及退行性疾病研究小组进行的一项合作研究。评估心脏、肾脏和血管TOD。测量外周和中心血压、眼底动静脉大小、氧化应激以及VAV - 2和VAV - 3基因的多态性。
本研究将在获得萨拉曼卡大学临床医院伦理委员会批准后进行。所有研究参与者将签署知情同意书，同意参与研究，并签署另一项同意书，同意进行基因研究，符合《赫尔辛基宣言》和世界卫生组织观察性研究标准。本研究结果将有助于了解不同TOD与血压、视网膜动静脉直径、氧化应激以及VAV - 2和VAV - 3基因多态性之间的关系。
ClinicalTrials.gov标识符：NCT02022618。
