Kelly Adam G
Continuum (Minneap Minn). 2014 Apr;20(2 Cerebrovascular Disease):387-98. doi: 10.1212/01.CON.0000446108.12915.65.
Unruptured intracranial aneurysms are found commonly in the general public, and more frequently in certain populations. This article focuses on the epidemiology, screening strategies, and management options for patients with unruptured aneurysms.
Recent epidemiologic studies show the overall prevalence of intracranial aneurysms to be approximately 3%, with higher rates seen in familial aneurysm syndromes and in certain medical conditions, such as autosomal dominant polycystic kidney syndrome. Aneurysm treatment may include surgical or endovascular techniques, with increasing utilization of endovascular strategies over time. Increased aneurysm diameter, certain locations, and other anatomical considerations may be associated with higher risks of aneurysm rupture.
Given the high morbidity and mortality associated with aneurysm rupture, screening for unruptured aneurysms is generally recommended for high-risk patients (patients who have at least two first-degree relatives with aneurysms, and patients with autosomal dominant polycystic kidney disease). Screening may be considered for other patients (eg, one first-degree relative with aneurysm) after discussion of the risks and benefits of imaging. Following identification of an aneurysm, decisions regarding observation or treatment should be based on patient characteristics, features of the aneurysm, and provider expertise.
未破裂颅内动脉瘤在普通人群中较为常见,在某些特定人群中更为频发。本文重点关注未破裂动脉瘤患者的流行病学、筛查策略及治疗选择。
近期流行病学研究表明,颅内动脉瘤的总体患病率约为3%,在家族性动脉瘤综合征及某些疾病(如常染色体显性遗传性多囊肾病)中发病率更高。动脉瘤治疗可包括外科手术或血管内治疗技术,随着时间推移,血管内治疗策略的应用日益增多。动脉瘤直径增大、特定位置及其他解剖学因素可能与动脉瘤破裂风险较高相关。
鉴于动脉瘤破裂相关的高发病率和死亡率,一般建议对高危患者(至少有两名患动脉瘤的一级亲属的患者,以及常染色体显性遗传性多囊肾病患者)进行未破裂动脉瘤筛查。对于其他患者(如患有动脉瘤的一名一级亲属),在讨论影像学检查的风险和益处后,可考虑进行筛查。发现动脉瘤后,关于观察或治疗的决策应基于患者特征、动脉瘤特点及医疗人员的专业知识。