Department of Ophthalmology, St. Vincent's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea.
Invest Ophthalmol Vis Sci. 2014 Apr 3;55(4):2041-7. doi: 10.1167/IOVS.13-12853.
To assess the relationship between serum level of 25-hydroxyvitamin D (25(OH)D) and refractive error in Korean adolescents.
A total of 2038 adolescent aged 13 to 18 years, who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011 underwent refractive examination using an autorefractor. Serum 25(OH)D concentration and other potential risk factors were examined. Multivariate regression analysis was performed to investigate the association between serum 25(OH)D and spherical equivalent (SE).
Among the participants, 80.1% had myopia (-0.5 diopters [D] or more myopic) and 8.9% had high myopia (-6.0 D or more myopia). Age, total energy/Ca intake, area of residence, parental income, and smoking experience were significantly different among groups according to SE (All, P < 0.05). The age-adjusted distribution of SE according to serum 25(OH)D concentration showed a positive relationship (r = 0.067, P = 0.012). The myopia group had a significant positive relationship between SE and serum 25(OH)D tertile concentration (P = 0.020), whereas the nonmyopia group did not have any significant relationship (P = 0.599). In multiple linear regression analyses, SE was significantly associated with low serum 25(OH)D concentration after adjustment for area of residence, parental income, total energy intake, dietary Ca intake, milk consumption, and smoking experience (P = 0.047). The prevalence of high myopia was significantly associated with the lowest tertile of serum 25(OH)D concentration after adjustment for the confounding factors (P = 0.017).
Low serum 25(OH)D concentration was associated with myopia prevalence in Korean adolescents. This relationship was particularly notable in adolescents with high myopia.
评估血清 25-羟维生素 D（25（OH）D）水平与韩国青少年屈光不正的关系。
共有 2038 名年龄在 13 至 18 岁的青少年参加了 2008 年至 2011 年的韩国国家健康和营养检查调查（KNHANES），他们使用自动折射仪进行了屈光检查。检查了血清 25（OH）D 浓度和其他潜在的危险因素。进行多元回归分析以研究血清 25（OH）D 与球镜等效（SE）之间的关系。
在参与者中，80.1%有近视（-0.5 屈光度[D]或更近视），8.9%有高度近视（-6.0 D 或更近视）。根据 SE（均，P <0.05），年龄、总能量/Ca 摄入量、居住地、父母收入和吸烟经历在各组之间差异显著。根据血清 25（OH）D 浓度调整年龄后的 SE 分布呈正相关（r = 0.067，P = 0.012）。近视组 SE 与血清 25（OH）D 三分位数浓度之间存在显著正相关（P = 0.020），而非近视组则无显著相关性（P = 0.599）。在多元线性回归分析中，在调整居住地、父母收入、总能量摄入、膳食 Ca 摄入、牛奶消费和吸烟经历后，SE 与低血清 25（OH）D 浓度显著相关（P = 0.047）。在调整混杂因素后，高血清 25（OH）D 浓度的最低三分位数与高度近视的患病率显著相关（P = 0.017）。
血清 25（OH）D 浓度低与韩国青少年近视患病率有关。这种关系在高度近视的青少年中尤为明显。
