Jones M, Leroux J
Faculty of Pharmacy, University of Montreal, Montreal, Canada.
Eur J Pharm Biopharm. 1999 Sep;48(2):101-11. doi: 10.1016/s0939-6411(99)00039-9.
Polymeric micelles have recently emerged as a novel promising colloidal carrier for the targeting of poorly water soluble and amphiphilic drugs. Polymeric micelles are considerably more stable than surfactant micelles and can solubilize substantial amounts of hydrophobic compounds in their inner core. Due to their hydrophilic shell and small size they sometimes exhibit prolonged circulation times in vivo and can accumulate in tumoral tissues. This review examines the chemical nature of polymeric micelles as well as the methods used to characterize them with regard to drug delivery. Special emphasis is put on the determination of critical micelle concentration and on drug loading procedures. Potential medical applications, especially in cancer chemotherapy, are described and discussed.
聚合物胶束最近已成为一种新型且有前景的胶体载体，用于靶向难溶于水的两亲性药物。聚合物胶束比表面活性剂胶束稳定得多，并且能够在其内核中溶解大量疏水化合物。由于其亲水外壳和小尺寸，它们有时在体内表现出延长的循环时间，并可在肿瘤组织中蓄积。本综述研究了聚合物胶束的化学性质以及用于药物递送方面表征它们的方法。特别强调了临界胶束浓度的测定和药物负载程序。描述并讨论了潜在的医学应用，尤其是在癌症化疗中的应用。
