STIM1 可刺激吞噬细胞 NADPH 氧化酶。
STIM1 for stimulation of phagocyte NADPH oxidase.
机构信息
SHANGHAI JIAO TONG UNIVERSITY;
出版信息
Blood. 2014 Apr 3;123(14):2129-30. doi: 10.1182/blood-2014-02-555789.
Abstract
In this issue of Blood, Zhang et al show that mice lacking the stromal-interacting molecule 1 (STIM1) gene in bone marrow cells are more susceptible to bacterial infection but are resistant to ischemia/reperfusion injury because of defective activation of phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.
摘要
在本期《Blood》中，Zhang 等人表明，骨髓细胞中缺乏基质相互作用分子 1（STIM1）基因的小鼠更容易受到细菌感染，但对缺血/再灌注损伤具有抗性，这是由于吞噬细胞烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶的激活缺陷所致。
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本文引用的文献
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STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.STIM1 钙传感器在炎症和宿主防御期间被激活吞噬细胞氧化酶所必需。
Blood. 2014 Apr 3;123(14):2238-49. doi: 10.1182/blood-2012-08-450403. Epub 2014 Feb 3.
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